惠幼A+  LSORS


Extremely low sodium hypotonic rehydration solution for young children
with acute gastroenteritis.
Author(s): Lin SL, Kong MS
Affiliation(s): Department of Pediatrics, Chang Gung Memorial Hospital, 222, Mai-Chin Road, Keelung, Taiwan,
R.O.C.
Publication date & source: 2001-05, Chang Gung Med J., 24(5):294-9.
Publication type: Clinical Trial; Randomized Controlled Trial
BACKGROUND: The clinical efficacy and safety of a low-sodium hypotonic oral rehydration solution (LSORS)
was compared in a pilot study with that of a standard World Health Organization oral rehydration solution
(STORS) in young children with acute diarrhea. METHODS: One hundred and seventeen boys aged 3 to 18
months with acute diarrhea were randomly assigned to groups and received low-sodium (sodium 28 mmol/L)
hypotonic oral rehydration solution and standard oral rehydration solution (sodium 90 mmol/L). Outcomes of
therapy such as stool volume, duration of diarrhea and fluid intake were recorded at 24 hours, 48 hours, and the
discontinuation of disease. Serum electrolytes levels were calculated before and after therapy. RESULTS: The stool
output (gm/kg) in the first 24 hours was 69.2 +/- 38.5 in the LSORS group versus 105 +/- 39.8 in the STORS group
(p < 0.05), while the total stool output during the 48-hour period was 151.4 +/- 68.9 in the LSORS group versus
232 +/- 97.3 in the STORS group (p < 0.05). No significant (p > 0.05) reduction in duration of diarrhea was noted
(72.3 +/- 25.5 hours versus 69.8 +/- 29.4 hours). Four patients in the LSORS group and 7 patients in the STORS
were classified as treatment failure. Forty-four (80%) achieved successful treatment in the LSORS group and 34
(56.7%) in the STORS group (p = 0.07). CONCLUSION: LSORS is as safe as STORS in treating young children
with acute gastroenteritis. No evidence of hyponatremia was found after patient received LSORS. LSORS afforded
more efficacious therapy than STORS.
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